IVF – ICSI and Preimplantation Genetic Diagnosis<\/h1><\/div>At our center, we combine the most advanced In Vitro Fertilization (IVF) techniques with genetic analysis of the embryos to offer you the best guarantee of success. IVF with Sperm Microinjection (ICSI) together with Preimplantation Genetic Testing for Aneuploidy (PGT-A) is a powerful strategy to increase pregnancy rates and reduce the risk of certain chromosomal abnormalities. <\/p>\n
This comprehensive approach allows us not only to facilitate fertilization, but also to select the embryos with the greatest potential for implantation and healthy development before transferring them to the uterus.<\/p>\n<\/div>
![](\"https:\/\/masfiv.com\/wp-content\/uploads\/2025\/01\/Depositphotos_100412280_L.jpg\" "\\"Artificial")
<\/span><\/div>What is PGT-A and why is it combined with IVF-ICSI?<\/h2><\/div>Preimplantation Genetic Diagnosis for Aneuploidy (PGT-A)<\/strong> is an analysis performed on embryos obtained through IVF before their transfer to the uterus. Its objective is to identify aneuploidies<\/strong>, which are alterations in the number of chromosomes (having too many or too few chromosomes). <\/p>\nAneuploidies are one of the main causes of:<\/p>\n
\n- Embryo implantation failure.<\/li>\n
- Miscarriages (especially in the first trimester).<\/li>\n
- Birth of babies with chromosomal syndromes (such as Down’s, Patau’s or Edwards’ Syndrome).<\/li>\n<\/ul>\n<\/div>
Why is ICSI essential for PGT-A?<\/h2><\/div>To perform PGT-A reliably, it is essential to use the ICSI technique (microinjection of a single sperm into the egg). In conventional IVF, many sperm can adhere to the outer layer of the egg, even if only one fertilizes the egg. These attached sperm could contaminate the cell sample that is biopsied from the embryo for genetic analysis, leading to erroneous results. ICSI ensures that only the genetic material from the sperm that fertilized the egg is present, guaranteeing maximum accuracy of the PGT-A analysis. <\/p>\n<\/div>
For whom is IVF-ICSI treatment with PGT-A indicated?<\/h2><\/h2><\/div>Although it can be considered in other cases, PGT-A is especially recommended in situations where the risk of embryonic aneuploidy is higher or where the aim is to optimize the transfer possibilities to the maximum:<\/p>\n<\/div>
- <\/i><\/span>\n
Advanced Maternal Age:<\/strong> Women 38 years of age or older, as the risk of egg aneuploidy increases significantly with age.<\/p>\n<\/div><\/li>- <\/i><\/span>Repeat Abortions:<\/strong> Couples who have suffered two or more miscarriages of unknown cause.<\/div><\/li>
- <\/i><\/span>Recurrent Implantation Failures:<\/strong> Couples who have had repeated implantation failures after transferring embryos of good morphological quality in previous IVF cycles.<\/div><\/li>
- <\/i><\/span>\n
Severe Male Factor:<\/strong> Some severe alterations in the semen may be associated with an increased risk of aneuploidy in the embryos.<\/p>\n<\/div><\/li>- <\/i><\/span>\n
Previous History of Aneuploid Pregnancy:<\/strong> Couples who have had a previous pregnancy with a chromosomal alteration.<\/p>\n<\/div><\/li>- <\/i><\/span>\n
Transfer Optimization:<\/strong> Couples who wish to maximize the probability of transfer pregnancy and reduce the risk of multiple pregnancy by transferring a single chromosomally normal (euploid) embryo.<\/p>\n <\/p>\n<\/div><\/li><\/ul>
Our team in Donostia will offer you personalized genetic and medical advice to assess whether PGT-A is the right option for your case.<\/p>\n<\/div><\/div><\/div>
At our center, we combine the most advanced In Vitro Fertilization (IVF) techniques with genetic analysis of the embryos to offer you the best guarantee of success. IVF with Sperm Microinjection (ICSI) together with Preimplantation Genetic Testing for Aneuploidy (PGT-A) is a powerful strategy to increase pregnancy rates and reduce the risk of certain chromosomal abnormalities. <\/p>\n
This comprehensive approach allows us not only to facilitate fertilization, but also to select the embryos with the greatest potential for implantation and healthy development before transferring them to the uterus.<\/p>\n<\/div>
<\/span><\/div>What is PGT-A and why is it combined with IVF-ICSI?<\/h2><\/div>Preimplantation Genetic Diagnosis for Aneuploidy (PGT-A)<\/strong> is an analysis performed on embryos obtained through IVF before their transfer to the uterus. Its objective is to identify aneuploidies<\/strong>, which are alterations in the number of chromosomes (having too many or too few chromosomes). <\/p>\nAneuploidies are one of the main causes of:<\/p>\n
\n- Embryo implantation failure.<\/li>\n
- Miscarriages (especially in the first trimester).<\/li>\n
- Birth of babies with chromosomal syndromes (such as Down’s, Patau’s or Edwards’ Syndrome).<\/li>\n<\/ul>\n<\/div>
Why is ICSI essential for PGT-A?<\/h2><\/div>To perform PGT-A reliably, it is essential to use the ICSI technique (microinjection of a single sperm into the egg). In conventional IVF, many sperm can adhere to the outer layer of the egg, even if only one fertilizes the egg. These attached sperm could contaminate the cell sample that is biopsied from the embryo for genetic analysis, leading to erroneous results. ICSI ensures that only the genetic material from the sperm that fertilized the egg is present, guaranteeing maximum accuracy of the PGT-A analysis. <\/p>\n<\/div>
For whom is IVF-ICSI treatment with PGT-A indicated?<\/h2><\/h2><\/div>Although it can be considered in other cases, PGT-A is especially recommended in situations where the risk of embryonic aneuploidy is higher or where the aim is to optimize the transfer possibilities to the maximum:<\/p>\n<\/div>
- <\/i><\/span>\n
Advanced Maternal Age:<\/strong> Women 38 years of age or older, as the risk of egg aneuploidy increases significantly with age.<\/p>\n<\/div><\/li>- <\/i><\/span>Repeat Abortions:<\/strong> Couples who have suffered two or more miscarriages of unknown cause.<\/div><\/li>
- <\/i><\/span>Recurrent Implantation Failures:<\/strong> Couples who have had repeated implantation failures after transferring embryos of good morphological quality in previous IVF cycles.<\/div><\/li>
- <\/i><\/span>\n
Severe Male Factor:<\/strong> Some severe alterations in the semen may be associated with an increased risk of aneuploidy in the embryos.<\/p>\n<\/div><\/li>- <\/i><\/span>\n
Previous History of Aneuploid Pregnancy:<\/strong> Couples who have had a previous pregnancy with a chromosomal alteration.<\/p>\n<\/div><\/li>- <\/i><\/span>\n
Transfer Optimization:<\/strong> Couples who wish to maximize the probability of transfer pregnancy and reduce the risk of multiple pregnancy by transferring a single chromosomally normal (euploid) embryo.<\/p>\n <\/p>\n<\/div><\/li><\/ul>
Our team in Donostia will offer you personalized genetic and medical advice to assess whether PGT-A is the right option for your case.<\/p>\n<\/div><\/div><\/div>
Preimplantation Genetic Diagnosis for Aneuploidy (PGT-A)<\/strong> is an analysis performed on embryos obtained through IVF before their transfer to the uterus. Its objective is to identify aneuploidies<\/strong>, which are alterations in the number of chromosomes (having too many or too few chromosomes). <\/p>\n Aneuploidies are one of the main causes of:<\/p>\n To perform PGT-A reliably, it is essential to use the ICSI technique (microinjection of a single sperm into the egg). In conventional IVF, many sperm can adhere to the outer layer of the egg, even if only one fertilizes the egg. These attached sperm could contaminate the cell sample that is biopsied from the embryo for genetic analysis, leading to erroneous results. ICSI ensures that only the genetic material from the sperm that fertilized the egg is present, guaranteeing maximum accuracy of the PGT-A analysis. <\/p>\n<\/div> Although it can be considered in other cases, PGT-A is especially recommended in situations where the risk of embryonic aneuploidy is higher or where the aim is to optimize the transfer possibilities to the maximum:<\/p>\n<\/div> Advanced Maternal Age:<\/strong> Women 38 years of age or older, as the risk of egg aneuploidy increases significantly with age.<\/p>\n<\/div><\/li> Severe Male Factor:<\/strong> Some severe alterations in the semen may be associated with an increased risk of aneuploidy in the embryos.<\/p>\n<\/div><\/li> Previous History of Aneuploid Pregnancy:<\/strong> Couples who have had a previous pregnancy with a chromosomal alteration.<\/p>\n<\/div><\/li> Transfer Optimization:<\/strong> Couples who wish to maximize the probability of transfer pregnancy and reduce the risk of multiple pregnancy by transferring a single chromosomally normal (euploid) embryo.<\/p>\n <\/p>\n<\/div><\/li><\/ul> Our team in Donostia will offer you personalized genetic and medical advice to assess whether PGT-A is the right option for your case.<\/p>\n<\/div><\/div><\/div>\n
Why is ICSI essential for PGT-A?<\/h2><\/div>
For whom is IVF-ICSI treatment with PGT-A indicated?<\/h2><\/h2><\/div>